This study develops mechanochemically reprogrammed stem cell exosomes that enhance immunomodulatory function and macrophage uptake for pulmonary fibrosis therapy.

DOI 10.64898/2026.03.20.713315

mouseexperimental assay

𝕏 PostBluesky

BioengineeringBioactive MaterialsPeer-reviewedAug 13, 2026

Interpretable AI driven materiomics to decode microenvironmental cues for stem cell immunomodulation

Chenxi Pan, Yi He, Yingying Duan…·Huanan Wang

This study uses AI to analyze hydrogel microenvironments and identifies matrix stiffness as key for enhancing MSC immunomodulation.

DOI 10.1016/j.bioactmat.2026.07.006

machine learning (classical)cell type annotation

𝕏 PostBluesky

BioinformaticsbioRxivPreprintJan 7, 2023

DPHL v2: An updated and comprehensive DIA pan-human assay library for quantifying more than 14,000 proteins.

Zhangzhi Xue, Tiansheng Zhu, Fangfei Zhang…·Tiannan Guo

DPHL v2 improves upon DPHL v1 by including semi-tryptic peptides and protein isoforms, increasing identified and dysregulated proteins in colorectal cancer analysis.

DOI 10.1101/2023.01.07.523067

humanproteomics

𝕏 PostBluesky

Systems BiologybioRxivPreprintMay 27, 2021

A comprehensive mass spectral library for human thyroid tissues

Yaoting Sun, Lu Li, Weigang Ge…·Tiannan Guo

The paper constructs a comprehensive mass spectral library for human thyroid tissues to improve the detection of malignant nodules through proteomic analysis.

1 citation

humanproteomics

𝕏 PostBluesky