Søren Thirup

The paper uses fragment-based methods to explore urethanase active sites and identifies diverse binding modes for polyurethane fragments.

EnZight identifies and prioritizes substitution hotspots in enzymes using structural alignment, demonstrating effectiveness in improving catalytic activity and thermostability.

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.