Mathias Kaas Ollendorff

The paper develops a SorCS2-derived macrocycle, TT-P34, which shows neuroprotective effects in animal models of neurodegeneration by enhancing mitochondrial function and reducing disease symptoms.

This paper develops SORTACs, small molecules that degrade extracellular proteins by hijacking the sortilin/progranulin interaction, showing nanomolar potency against TNFα.

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.

This study identifies a triple serine motif in SorCS1-3 intracellular domains that regulates neurotrophic signaling through phosphorylation, leading to CREB activation and BDNF pathway modulation.

This study shows that loss of SORCS2 increases DNA double-strand breaks in neurons, linking it to neurodegenerative processes.