Indrani Datta

This study shows that the LRRK2-I1371V mutation impairs astrocytic glucose metabolism and causes multi-organellar dysfunction in Parkinson's disease.

This study identifies miR-126-3p as a biomarker for knee osteoarthritis, showing elevated levels in patients and reduced disease severity with mimic treatment.

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

This study uses untargeted metabolomics to identify altered serum metabolites distinguishing relapsing-remitting MS, progressive MS, and healthy subjects.

The paper identifies altered omega fatty acid-derived lipid mediators in RRMS patients using metabolipidomics, suggesting their potential as biomarkers for diagnosis and prognosis.

The paper identifies altered metabolic pathways in RRMS patients using metabolomics and shows that targeting glycolysis can reduce disease progression in a mouse model.