Oluwademilade Nuga

This study uses RNA-seq to analyze transcriptomic changes in HEK293T cells with mutant Atrophin-1, identifying disruptions in multiple pathways linked to DRPLA pathology.

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

This paper develops a Drosophila model of DRPLA by expressing human ATN1 with normal or pathogenic polyglutamine repeats, showing that pathogenic ATN1 causes toxicity and identifies potential therapeutic targets.

The paper investigates how linear ubiquitin chains affect the proteome in Drosophila by analyzing proteomic changes in flies expressing chains of different lengths.