Author

Rebecca L. Bigler

University of North Carolina at Chapel HillORCID 0000-0002-0075-6188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:electronic health records· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Anne Marion TayloriD· 2 shared Benjamin D. PhilpotiD· 1 shared Joyce W. Kamande· 1 shared Mark Niedringhaus· 1 shared Raluca Dumitru· 1 shared Randolph J. NudoiD· 1 shared Rylan S. LarseniD· 1 shared Shawn B. FrostiD· 1 shared

Activity by Year

2016-2017 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Anne Marion TaylorORCID

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2 papers

Recent·Most cited

Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling

Tharkika Nagendran, Rylan S. Larsen, Rebecca L. Bigler, Shawn B. Frost, Benjamin D. Philpot, Randolph J. Nudo, Anne Marion Taylor

This study shows that axotomy leads to dendritic spine loss and presynaptic hyper-excitability in injured neurons, which can be normalized by exogenous netrin-1.

Nature Communications · Sep 14, 2017Peer-reviewedNeuroscience

Axonal transcriptome of human stem cell derived neurons

Rebecca L. Bigler, Joyce W. Kamande, Raluca Dumitru, Mark Niedringhaus, Anne Marion Taylor

The paper identifies axonal mRNAs in human neurons using microfluidic chambers and RNA-FISH, finding conserved and novel transcripts compared to rat neurons.

bioRxiv · Nov 28, 2016 · PreprintNeuroscience