Inheritance of OCT4 predetermines fate choice in human embryonic stem cells
Samuel C. Wolff, Katarzyna M. Kedziora, Raluca Dumitru, Cierra D. Dungee, Tarek M. Zikry, Adriana S. Beltrán, Rachel A. Haggerty, JrGang Cheng, Margaret A. Redick, Jeremy E. Purvis
The paper shows that OCT4 inheritance predetermines fate choice in human embryonic stem cells, with higher OCT4 ratios in daughters leading to sustained pluripotency and reduced differentiation potential.
Molecular Systems Biology · Sep 1, 2018Peer-reviewedSystems Biology