Chima V. Maduka

Engineered endosymbionts that modulate primary macrophage function and attenuate tumor growth by shifting the tumor microenvironment

This study develops engineered endosymbionts that modulate macrophage function and reduce tumor growth by altering the tumor microenvironment in a murine model.

Persistent endotoxin exposure in macrophages elicits an immunometabolic profile susceptible to NF-kB and p53 perturbation

This study shows that persistent LPS exposure in macrophages leads to a unique immunometabolic profile with altered oxygen consumption, ATP levels, and glycolysis, distinct from short-term LPS responses.

Engineering nanoparticles that target fibroblast activation protein in cardiac fibrosis

This paper develops anti-FAP antibody-modified nanoparticles that target cardiac fibrosis in a rat model, reducing talabostat dose by 400,000-fold and reversing fibrosis and dysfunction.

The role of mitochondrial complex I in the proinflammatory response to polylactide implants

This study investigates how PLA degradation products affect macrophage metabolism and inflammation, showing distinct metabolic responses to amorphous and semi-crystalline PLA.