Ashley V. Makela

VesicleVoyager: In vivo selection of surface displayed proteins that direct extracellular vesicles to tissue-specific targets

The paper develops a method to select tissue-specific proteins that direct extracellular vesicles in vivo, using EV-display libraries and a Markov chain model to predict selection dynamics.

Engineered endosymbionts that modulate primary macrophage function and attenuate tumor growth by shifting the tumor microenvironment

This study develops engineered endosymbionts that modulate macrophage function and reduce tumor growth by altering the tumor microenvironment in a murine model.

Persistent endotoxin exposure in macrophages elicits an immunometabolic profile susceptible to NF-kB and p53 perturbation

This study shows that persistent LPS exposure in macrophages leads to a unique immunometabolic profile with altered oxygen consumption, ATP levels, and glycolysis, distinct from short-term LPS responses.

The role of mitochondrial complex I in the proinflammatory response to polylactide implants

This study investigates how PLA degradation products affect macrophage metabolism and inflammation, showing distinct metabolic responses to amorphous and semi-crystalline PLA.

Magnetic particle imaging reveals that iron-labeled extracellular vesicles accumulate in brains of mice with metastases

This paper uses magnetic particle imaging to show that iron-labeled extracellular vesicles accumulate in brains of mice with brain metastases but not in mice without metastases.