Fructose utilization by GM-CSF-differentiated macrophages aggravates autoimmune inflammation via MG-derived AGE-RAGE signaling
Yeon Jun Kang, Sihyun Chae, Jaemoon Koh, Woogil Song, Y Li, Jin‐Hwa Kim, Hee Young Kim, Dongjin Jeong, Jong-Wan Park, Eun Young Lee, Doo Hyun Chung, Seong Wook Kang, Jin Kyun Park, Jeong Seok Lee, Joo‐Youn Cho, Won-Woo Lee
This study shows fructose metabolism in GM-CSF-differentiated macrophages promotes autoimmune inflammation through MG-AGE-RAGE signaling by enhancing glycolysis and Th17 differentiation.
bioRxiv · Jan 28, 2026 · PreprintImmunology