Compartmentalized glycolysis powers ATP production in primary cilia and engages mitochondria via the phosphoenolpyruvate cycle
Shih Ming Huang, Hannah R. Foster, Eun Young Lee, Jeong Hun Jo, Xinhang Dong, Byoung-Kyu Cho, Young Ah Goo, Jing W. Hughes, MATTHEW J. MERRINS
The paper shows primary cilia use localized glycolysis and mitochondrial PEP to generate ATP, and can access ATP from the cell body when glucose is limited.
bioRxiv · May 11, 2026 · PreprintCell Biology