Spencer T. Seiler

Multiscale Cloud-based Pipeline for Neuronal Electrophysiology Analysis and Visualization

The paper presents a cloud-based pipeline for analyzing and visualizing neuronal electrophysiology data from HD-MEAs, demonstrating its utility in simplifying data analysis and understanding neural activity.

Servo-Actuated 3D-Printed Disposable Microvalves for Automated, Scalable Organoid Culture in Standard Incubators

This paper develops a 3D-printed, servo-actuated microvalve system for automated organoid culture, validated in mouse and human models with comparable viability and gene expression to manual methods.

Microfluidic Control of Dorsal-Ventral Patterning Within a Single Forebrain Organoid

This study develops a microfluidic platform to induce spatially segregated ventral and dorsal domains in mouse forebrain organoids without fusion, enabling study of tissue regionalization.

A Modular In-Incubator Microscope for Longitudinal Live Cell Microscopy

This paper introduces an automated in-incubator microscope for long-term live cell imaging, enabling high-frequency, continuous data collection with improved thermal stability and operational reliability.

A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring

This paper introduces an automated brain organoid platform with IoT integration for continuous monitoring and control, showing increased neural activity and stable firing rates during automated media exchange.

Dual RNA-Seq analysis of SARS-CoV-2 correlates specific human transcriptional response pathways directly to viral expression

This study uses dual RNA-seq to analyze co-regulation of human and SARS-CoV-2 genes, identifying tissue-specific expression patterns and potential therapeutic targets.