Weiguang Zeng

The paper isolates soil bacteria using diffusion chambers, screens for antibiotic activity, and combines mass spectrometry and genomics to identify known and novel antibiotics from Australian soil samples.

This study uses bioluminescent Mycobacterium ulcerans in a mouse tail model to monitor Buruli ulcer progression and evaluate immune responses.

The paper demonstrates that a low dose of Mycobacterium ulcerans can cause Buruli ulcer through skin punctures from mosquito bites or needles in mice.