Author

Tine Curk

Johns Hopkins UniversityORCID 0000-0002-2167-5336Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Hai‐Quan MaoiD· 2 shared Jinghan LiniD· 2 shared Sixuan LiiD· 2 shared Turash Haque PialiD· 2 shared Di YuiD· 1 shared Jeff WangiD· 1 shared Jingyao MaiD· 1 shared Kailei D. GoodieriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Hai‐Quan MaoORCID

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2 papers

Recent·Most cited

Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA-Based Therapeutics

Turash Haque Pial, Sixuan Li, Jinghan Lin, Tza-Huei Wang, Hai‐Quan Mao, Tine Curk

This study identifies the causes of payload heterogeneity in lipid nanoparticles and proposes methods to improve RNA distribution uniformity.

Advanced Functional Materials · Jan 16, 2026Peer-reviewedBioengineering

Buffer Valency Engineering Enables High-concentration and Shelf-stable DNA Transfection Particles for Viral Vector Production

Jinghan Lin, Yizong Hu, Turash Haque Pial, Kailei D. Goodier, Di Yu, Marine Guise, Paetra Brailsford, Maria Choi-Ali, Sixuan Li, Yining Zhu, Jingyao Ma, Leonardo Cheng, Xiaoya Lu, Nicole Korinetz, Jeff Wang, , Hai‐Quan Mao

This paper develops a method to create high-concentration, shelf-stable DNA transfection particles for AAV production, achieving tenfold higher pDNA concentration and reduced dosing volume.

bioRxiv · Jul 2, 2025 · PreprintBiochemistry