A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Ernest Iu, Alexander Bogatch, Wenjun Deng, Jonathan D. Humphries, Changsong Yang, Fernando R. Valencia, Chengyin Li, Christopher A. McCulloch, Guy Tanentzapf, Tatyana Svitkina, Martin James Humphries, Sergey V. Plotnikov
The paper identifies a TRPV4-dependent Ca2+ signaling pathway that regulates lamellipodia actin architecture and promotes cell migration through RhoA and formin-mediated actin assembly.
Current Biology · Feb 1, 2026Peer-reviewedCell Biology