This paper introduces a high-speed two-photon microscope using adaptive line-excitation to image neural activity in mouse cortex, increasing imaging speed and reducing laser power.

Optica · Jul 1, 2024Peer-reviewedNeuroscience

α1 adrenergic receptor - PKC - Pyk2 - Src signaling boosts L-type Ca2+ channel Cav1.2 activity and long-term potentiation in rodents

Kwun Nok Mimi Man, Peter Bartels, Peter B. Henderson, Karam Kim, Mei Shi, Mingxu Zhang, Sheng‐Yang Ho, Madeline Nieves‐Cintrón, Manuel F. Navedo, Mary C. Horne, Johannes Wilhelm Hell

This study identifies the α1 adrenergic receptor - PKC - Pyk2 - Src signaling pathway as a mechanism boosting CaV1.2 channel activity and LTP in rodents.

eLife · Jun 20, 2023Peer-reviewedNeuroscience

Alpha-Actinin-1 promotes activity of the L-type Ca2+ Channel CaV1.2

Matthew Turner, David E. Anderson, Peter Bartels, Madeline Nieves‐Cintrón, Andrea M. Coleman, Peter B. Henderson, Kwun Nok Mimi Man, Pang‐Yen Tseng, Vladimir M. Yarov-Yarovoy, Donald M. Bers, Manuel F. Navedo, Mary C. Horne, James B. Ames, Johannes Wilhelm Hell

The paper shows that Alpha-Actinin-1 enhances CaV1.2 channel activity by localizing it to specific sites and increasing its open probability.

The EMBO Journal · Jan 27, 2020Peer-reviewedMolecular Biology