Manuel F. Navedo

This study identifies sex-specific cAMP signaling differences in vascular smooth muscle, showing female-specific SR cAMP pools and their hormonal regulation.

This paper identifies an intracellular mechanosensory complex in intestinal smooth muscle that amplifies signaling from the sarcoplasmic reticulum, independent of extracellular calcium, to regulate contractility.

This study identifies a pressure-sensitive regulatory mechanism of L-type Ca2+ channels that influences cerebral blood flow control and cognitive function.

This paper identifies a mechanism by which amyloid beta potentiates CaV1.2 channels via β2AR, leading to synaptic dysfunction and neurotoxicity, and shows that disrupting this pathway prevents these effects.

This study identifies the α1 adrenergic receptor - PKC - Pyk2 - Src signaling pathway as a mechanism boosting CaV1.2 channel activity and LTP in rodents.

The paper shows neurons in the mouse brain receive nuclear and ribosomal material from oligodendrocytes, which persists into adulthood and occurs in specific brain regions.

The paper shows that Alpha-Actinin-1 enhances CaV1.2 channel activity by localizing it to specific sites and increasing its open probability.