Geroprotective drug discovery with an AI-enabled assay for heat resistance
Thomas James Hodder, Allancer Nunes, Bryan Martinez, Karla J. Opperman, Paul D. Robbins, Chad L. Myers, Matthew S. Gill
This paper develops an AI-enabled platform to screen FDA-approved drugs for geroprotective effects, identifying 31 compounds that increase heat resistance in C. elegans and show anti-senescent activity in human cells.
bioRxiv · Aug 10, 2026 · PreprintPharmacology & Toxicology