Author

Karla J. Opperman

Seattle Children's HospitalORCID 0000-0001-9545-8361Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brock J. GrilliD· 2 shared Joseph S. PakiD· 2 shared Allancer NunesiD· 1 shared Bryan MartineziD· 1 shared Chad L. MyersiD· 1 shared Charu KapiliD· 1 shared Damon T. PageiD· 1 shared Elyse L. ChristenseniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Brock J. GrillORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintAug 10, 2026

Geroprotective drug discovery with an AI-enabled assay for heat resistance

Thomas James Hodder, Allancer Nunes, Bryan Martinez…·Matthew S. Gill

This paper develops an AI-enabled platform to screen FDA-approved drugs for geroprotective effects, identifying 31 compounds that increase heat resistance in C. elegans and show anti-senescent activity in human cells.

DOI 10.64898/2026.08.10.743574

C. elegansexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 28, 2025

UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viability

Joseph S. Pak, Seamus R. Morrone, Karla J. Opperman…·Brock J. Grill

This study identifies UBR-1 as a hub regulating glutamate homeostasis through a signaling axis, affecting locomotion and developmental viability in C. elegans.

DOI 10.1101/2025.07.28.666006

C. elegansproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 15, 2023

Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub

Jonathan Amezquita, Muriel Desbois, Karla J. Opperman…·Brock J. Grill

The paper identifies genetic and proteomic interactions between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub in C. elegans neurons, showing their role in axon development and neurodevelopmental disorders.

DOI 10.1101/2023.11.15.566604

C. elegansproteomics

𝕏 PostBluesky