Allancer Nunes

This paper develops an AI-enabled platform to screen FDA-approved drugs for geroprotective effects, identifying 31 compounds that increase heat resistance in C. elegans and show anti-senescent activity in human cells.

This study identifies lipid senolytics that kill senescent cells via ferroptosis, extending healthspan in mice by targeting ACSL4, LPCAT3, and ALOX15.

This study identifies fucoidans as senotherapeutics that enhance SIRT6-dependent DNA repair and reduce senescence in aged mice.

This study develops two novel flavonoid senolytics through phenotypic drug screening and design, showing enhanced senolytic activity and healthspan extension in a mouse model.

This study investigates the effects of dasatinib plus quercetin on uterine fibrosis in aged mice, showing increased p53 expression and reduced miR34a levels.