This study conducts a meta-analysis of mitochondrial DNA copy number in blood samples from individuals with mood disorders, finding increased mtDNAcn in MDD and BD Type II, and decreased in BD Type I.

Psychiatry Research · Jan 1, 2024Peer-reviewedNeuroscience

Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice

Jimmy Olusakin, Gautam Kumar, Mahashweta Basu, Cali A. Calarco, Megan E. Fox, Jason Bondoc Alipio, Catherine W. Haga, Makeda D. Turner, Asaf Keller, Seth A. Ament, Mary Kay Lobo

This study examines transcriptomic changes in reward and sensory brain regions of juvenile mice exposed to perinatal fentanyl, revealing sex-specific gene expression patterns and enriched biological processes.

Neuropsychopharmacology · Jul 3, 2023Peer-reviewedNeuroscience

Transcriptome profiling of the ventral pallidum reveals a role for pallido-thalamic neurons in cocaine reward

Michel Engeln, Megan E. Fox, Ramesh Chandra, Eric Y. Choi, Hyungwoo Nam, Houman Qadir, Shavin Thomas, Victoria M. Rhodes, Makeda D. Turner, Rae J. Herman, Cali A. Calarco, Mary Kay Lobo

This study identifies Nr4a1's role in cocaine reward by analyzing VP gene expression and manipulating Nr4a1 in specific neurons.

Molecular Psychiatry · Jun 28, 2022Peer-reviewedNeuroscience

Negative emotional behavior during fentanyl abstinence is mediated by adaptations in nucleus accumbens neuron subtypes

Megan E. Fox, Andreas B. Wulff, Daniela Franco, Eric Y. Choi, Cali A. Calarco, Michel Engeln, Makeda D. Turner, Ramesh Chandra, Victoria M. Rhodes, Scott M. Thompson, Seth A. Ament, Mary Kay Lobo

This study identifies molecular and structural changes in nucleus accumbens neuron subtypes during fentanyl abstinence that mediate negative emotional behaviors.

bioRxiv · May 15, 2022 · PreprintNeuroscience