Ramesh Chandra

The paper investigates nicotinic receptor responses in fast-spiking neurons of rat somatosensory cortex across development, finding presynaptic regulation but no postsynaptic responses despite receptor expression.

The paper uses CRISPR tools to mimic cocaine-induced bidirectional regulation of Nab2 and Egr3 in specific NAc MSN subtypes.

This study identifies Nr4a1's role in cocaine reward by analyzing VP gene expression and manipulating Nr4a1 in specific neurons.

This study identifies molecular and structural changes in nucleus accumbens neuron subtypes during fentanyl abstinence that mediate negative emotional behaviors.

This study identifies distinct transcriptomic, physiological, and functional properties of four VP projections and shows their opposing roles in cocaine withdrawal.

This study shows cocaine affects mitochondrial dynamics in neurons by regulating Egr3 transcription of mitochondrial-related genes, with distinct effects in D1-MSNs and D2-MSNs.

The paper investigates how TrkB deletion in D1-MSNs leads to stereotypy behavior and identifies molecular and morphological changes in these neurons.

The paper compares RNAseq methods for analyzing medium spiny neurons in the nucleus accumbens, finding that nuclear-FACS-seq identifies more differentially expressed genes and GWAS hits than other methods.