Author

Alec J. Vaughan

Brigham Young UniversityORCID 0000-0002-0154-8911Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Thales Y. PapagiannakopoulosiD· 2 shared Addison G. StameyiD· 1 shared Adrienne D. CoxiD· 1 shared Aikaterini ZiogouiD· 1 shared Andrew J. AguirreiD· 1 shared Andrew J. TrevelyaniD· 1 shared Andrew M. WatersiD· 1 shared Antje SchaeferiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Thales Y. PapagiannakopoulosORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 21, 2026

Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer

Wen-Hsuan Chang, Alec J. Vaughan, Addison G. Stamey…·Channing J. Der

This study identifies KEAP1 loss as a resistance mechanism to KRAS inhibitors in pancreatic and lung cancer and shows that combining glutamine inhibition with KRAS inhibitors can overcome this resistance.

1 citation

humanbulk RNA-seq

Cancer BiologyNaturePeer-reviewedNov 5, 2025

✦ In-depth digest

Targeting FSP1 triggers ferroptosis in lung cancer

Katherine Wu, Alec J. Vaughan, Jozef P. Bossowski…·Thales Y. Papagiannakopoulos

Genetic deletion or pharmacological inhibition of ferroptosis suppressor protein 1 (FSP1) induces lipid peroxidation and restricts lung adenocarcinoma growth in vivo, establishing FSP1 as a therapeutic vulnerability.

93 citationstop 1%

mousehuman

NeurosciencebioRxivPreprintNov 20, 2023

RNA sequencing demonstrates ex vivo neocortical transcriptomic changes induced by epileptiform activity in male and female mice

Alec J. Vaughan, Laura J. McMeekin, Kutter Hine…·R. Ryley Parrish

The paper uses RNA sequencing to analyze transcriptomic changes in mouse neocortical tissue exposed to epileptiform activity, identifying gene expression alterations linked to epilepsy.

DOI 10.1101/2023.11.20.567411

mousebulk RNA-seq