Thales Y. Papagiannakopoulos

This study identifies KEAP1 loss as a resistance mechanism to KRAS inhibitors in pancreatic and lung cancer and shows that combining glutamine inhibition with KRAS inhibitors can overcome this resistance.

This study shows aging promotes KRAS-driven lung cancer metastasis via ATF4 induction, which can be inhibited by glutaminase blockade.

Genetic deletion or pharmacological inhibition of ferroptosis suppressor protein 1 (FSP1) induces lipid peroxidation and restricts lung adenocarcinoma growth in vivo, establishing FSP1 as a therapeutic vulnerability.

This paper enhances the Eco1 retron editor for precise genome editing in human cells by improving ncRNA stability and reducing sgRNA extension, achieving editing without double-strand breaks.

This study shows that cysteine restriction in mice causes rapid weight loss by depleting glutathione and coenzyme A, activating stress responses, and increasing lipolysis.

This study identifies FMO4 as a driver of lung adenocarcinoma by stabilizing the MAT2A/MAT2B complex and inhibiting ferroptosis.

This study identifies inflammation in tumor-adjacent lung tissue as a predictor of clinical outcome in lung adenocarcinoma using multi-omic analysis of 143 stage I cases.

The paper shows NRF2 activation in KEAP1 wildtype lung cancers causes NADH-reductive stress, making them vulnerable to Complex I inhibition.

This study investigates how antibody concentration, staining volume, and cell number affect signal quality in oligo-conjugated antibody single-cell analysis, offering guidelines to reduce background and improve sensitivity.