Cancer BiologybioRxivPreprint
Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer
Wen-Hsuan Chang, Alec J. Vaughan, Addison G. Stamey…·Channing J. Der
This study identifies KEAP1 loss as a resistance mechanism to KRAS inhibitors in pancreatic and lung cancer and shows that combining glutamine inhibition with KRAS inhibitors can overcome this resistance.
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