Author

Antje Schaefer

University of North Carolina at Chapel HillORCID 0000-0002-2716-9899Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Abigail Ballard-KordeliskiiD· 1 shared Addison G. StameyiD· 1 shared Adrienne D. CoxiD· 1 shared Alec J. VaughaniD· 1 shared Andrew J. AguirreiD· 1 shared Andrew M. WatersiD· 1 shared Brian Matthew WolpiniD· 1 shared Channing J. DeriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

Abigail Ballard-KordeliskiORCID

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2 papers

Recent·Most cited

Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer

Wen-Hsuan Chang, Alec J. Vaughan, Addison G. Stamey, Mariana Mancini, Makiko Hayashi, Runying Y. Yang, Ryan N. Robb, Daniel Andrussier, Jeffrey A. Klomp, Andrew M. Waters, Antje Schaefer, Brian Matthew Wolpin, Kirsten L. Bryant, Adrienne D. Cox, Fernando Moreira Simabuco, , Channing J. Der

This study identifies KEAP1 loss as a resistance mechanism to KRAS inhibitors in pancreatic and lung cancer and shows that combining glutamine inhibition with KRAS inhibitors can overcome this resistance.

bioRxiv · Apr 21, 2026 · PreprintCancer Biology

RAP1-RHO small GTPase cross-talk mediates integrin-dependent and -independent platelet procoagulant response

Abigail Ballard-Kordeliski, Nikola Ziegmann, Wyatt J. Schug, Mark H. Ginsberg, Antje Schaefer, Robert H. Lee, Wolfgang Bergmeier

This study shows RAP1 regulates platelet PtdSer exposure and procoagulant activity through RHOA/integrin-dependent and -independent mechanisms.

Haematologica · Mar 5, 2026Peer-reviewedCell Biology