Simone Spuler

This paper develops hPep-based nanoparticles for efficient delivery of gene editors across multiple cell types, achieving high editing efficiency in human cells.

This study uses CRISPR to correct a dysferlin mutation in muscle stem cells, rescuing protein function and improving muscle regeneration in a mouse model.

The paper uses snRNAseq to identify nuclear subtypes in skeletal muscle cells, revealing new compartments and functional signatures in dystrophic and regenerating muscle.

This study shows statins alter gene and protein expression in human muscle cells, with a prostaglandin F2 alpha analog potentially mitigating these effects.