The paper identifies chemicals enriched for dementia-related genes and pathways using the Comparative Toxicogenomics Database, finding many chemicals associated with Alzheimer's disease and tauopathies.

Alzheimer s & Dementia · Aug 1, 2026Peer-reviewedGenomics

Perinatal Lead (Pb) Exposure Increases Mouse Embryonic Weight and Alters Neuronal Gene Expression

Bambarendage P. U. Perera, Minghua Li, Anagha Tapaswi, Junru Pan, Dongyue Wang, Tejas Goswami, Rachel K. Morgan, Kelly M. Bakulski, Jaclyn M. Goodrich, Maureen A. Sartor, Dana C. Dolinoy, Justin A. Colacino

This study shows that perinatal lead exposure increases mouse embryonic weight and alters gene expression in neuronal and sexually dimorphic pathways.

bioRxiv · Sep 18, 2025 · PreprintGenetics

Environmentally Relevant Lead Exposure Impacts Gene Expression in SH-SY5Y Cells Throughout Neuronal Differentiation

Rachel K. Morgan, Anagha Tapaswi, Katelyn M. Polemi, Jenna L Miller, Jonathan Sexton, Kelly M. Bakulski, Laurie K. Svoboda, Dana C. Dolinoy, Justin A. Colacino

This study examines how environmentally relevant lead exposure affects gene expression in SH-SY5Y cells during neuronal differentiation, finding stage-specific and persistent changes in gene expression and pathway enrichment.

Toxicological Sciences · May 21, 2025Peer-reviewedPharmacology & Toxicology

Environmentally Relevant Lead Exposure Alters Cell Morphology and Expression of Neural Hallmarks During SH-SY5Y Neuronal Differentiation

Rachel K. Morgan, Anagha Tapaswi, Katelyn M. Polemi, Jenna L. Miller, Jonathan Z. Sexton, Kelly M. Bakulski, Laurie Kathleen Svoboda, Dana C. Dolinoy, Justin A. Colacino

This study examines how different levels of lead exposure affect neural differentiation in SH-SY5Y cells, showing significant changes in protein expression and cell morphology.

bioRxiv · Feb 17, 2025 · PreprintNeuroscience