Maureen A. Sartor

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

The paper constructs a comprehensive TFBS database by integrating multiple resources and evaluates their accuracy using independent datasets.

This study examines HPV integration in HNSCC using RNA-seq data to link splicing events and expression ratios to poor clinical outcomes.

This study shows that HPV16 E6 splicing variants influence oropharyngeal cancer aggressiveness by altering E-cadherin localization and clinical outcomes.

This paper develops a machine learning classifier to subtype HPV+ HNSCC tumors into IMU or KRT using bulk RNA-seq data and validates its accuracy across multiple cohorts.

This study shows that perinatal lead exposure increases mouse embryonic weight and alters gene expression in neuronal and sexually dimorphic pathways.

The paper characterizes persistent epigenomic and transcriptomic changes in mice exposed to environmental toxicants across life stages, revealing widespread gene expression and chromatin alterations.

This study examines how perinatal exposure to lead or DEHP affects age-related DNA methylation and gene expression in mouse hearts, revealing sex-specific differences.

This study identifies autophagy as a critical survival pathway in mIDH1 gliomas and shows that inhibiting autophagy enhances radiosensitivity and tumor regression in preclinical models.

IndepthPathway improves pathway enrichment analysis for single-cell and bulk RNA-seq by addressing noise and low coverage issues through the WCSEA algorithm.

The paper develops genome-wide enhancer-to-target gene assignments across >500 cell types and shows they outperform naive methods in gene set enrichment analysis.

Poly-Enrich improves gene set enrichment testing for genomic regions by modeling peak counts with a negative binomial model, outperforming previous methods in certain scenarios.

The paper shows IDH1R132H mutation in glioma improves survival and DNA repair by enhancing ATM signaling and radioresistance, which can be reversed by inhibiting ATM or CHK1/2.

The paper uses single-cell RNA sequencing to analyze ALDH+ and CD44+CD24- populations in normal human breast tissue, revealing heterogeneity and hybrid epithelial/mesenchymal cells with stemness and EMT features.

annotatr summarizes and visualizes genomic region annotations, offering faster and more flexible analysis than existing tools.