Dana C. Dolinoy

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

This study shows that perinatal lead exposure increases mouse embryonic weight and alters gene expression in neuronal and sexually dimorphic pathways.

The paper characterizes persistent epigenomic and transcriptomic changes in mice exposed to environmental toxicants across life stages, revealing widespread gene expression and chromatin alterations.

This study examines how environmentally relevant lead exposure affects gene expression in SH-SY5Y cells during neuronal differentiation, finding stage-specific and persistent changes in gene expression and pathway enrichment.

The paper shows early-life toxicant exposure reprograms epigenomic aging, altering gene expression in liver cells and disease risk in adulthood.

This study examines how different levels of lead exposure affect neural differentiation in SH-SY5Y cells, showing significant changes in protein expression and cell morphology.

The paper develops a DNA methylation reference panel for placental tissues to estimate cell composition from bulk DNAm data, showing improved performance over existing methods.

This study examines how perinatal exposure to lead or DEHP affects age-related DNA methylation and gene expression in mouse hearts, revealing sex-specific differences.

The paper deconvolves placental gene expression data to show cell type proportions drive preeclampsia gene expression differences, reducing differentially expressed genes after adjustment.

This study shows perinatal lead exposure causes sex-specific DNA methylation changes in adult mouse liver and blood, with some methylation sites overlapping between tissues.