OPN3 mediates retinal-dependent lipofuscin accumulation and its loss sensitizes keratinocytes to blue-light-induced proteomic remodeling
Maiza Cristina Von Dentz, Helena C. Junqueira, Manuel Alejandro Herrera López, Gabriella Lisboa dos Santos, Johannes Fuchs, Katherine Tsantarlis, Carina Sihlbom, Leonardo Vinícius Monteiro de Assis, Maurı́cio S. Baptista
This study shows OPN3 promotes lipofuscin accumulation in keratinocytes under blue light and its loss reduces proteomic stress responses and lipofuscin formation.
bioRxiv · Sep 15, 2026 · PreprintCell Biology