Alex Inague

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

This paper develops LIPTACs, LDLR-targeting chimeras that enhance lysosomal delivery and cytotoxicity for cancer treatment by combining eTPD and ADC strategies.

The paper identifies oxysterol and LBP changes in SOD1G93A ALS rats, linking them to neuroinflammation and intestinal permeability during disease progression.

This study compares the effects of ergosterol, 7-dehydrocholesterol, and cholesterol under oxidative stress in melanoma cells, showing endoperoxides from these sterols are more effective in reducing cell viability.

The paper identifies PRDX6 as an alternative pathway for selenocysteine metabolism that contributes to ferroptosis resistance in cancer cells.