Author

Valentina Sepe

Federico II University HospitalORCID 0000-0002-0169-4441Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Approach:mixed model· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Angela ZampellaiD· 2 shared Bianca FiorilloiD· 2 shared Bruno CatalanottiiD· 2 shared Stefano FiorucciiD· 2 shared Bruno CharlieriD· 1 shared Carmen FestaiD· 1 shared Carmen Massa· 1 shared Cristina Di GiorgioiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Angela ZampellaORCID

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2 papers

Recent·Most cited

From Structure to Dynamics: Activation Mechanism of the G Protein-Coupled Bile Acid Receptor 1-Gs Complex

Bianca Fiorillo, Federica Moraca, Francesco Saverio Di Leva, Valentina Sepe, Stefano Fiorucci, Vittorio Limongelli, Angela Zampella, Bruno Catalanotti

This study investigates how lithocholic acid modulates GPBAR1 activation and G protein engagement through molecular dynamics simulations and structural analysis.

ACS Omega · Aug 13, 2026Peer-reviewedBioinformatics

A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease

Michele Biagioli, Cristina Di Giorgio, Carmen Massa, Silvia Marchianò, Rachele Bellini, Martina Bordoni, Ginevra Urbani, Rosalinda Roselli, Ginevra Lachi, Elva Morretta, Fabrizio Dal Piaz, Bruno Charlier, Bianca Fiorillo, Bruno Catalanotti, Luigi Cari, , Stefano Fiorucci

This study identifies 3-oxo-DCA as a microbial bile acid that acts as a GPBAR1 agonist and RORγt inverse agonist, reversing inflammation in IBD.

Biomedicine & Pharmacotherapy · Dec 1, 2024Peer-reviewedImmunology