Author

Stefano Fiorucci

University of PerugiaORCID 0000-0003-3816-4222Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Approach:mixed model· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Angela ZampellaiD· 2 shared Bianca FiorilloiD· 2 shared Bruno CatalanottiiD· 2 shared Valentina SepeiD· 2 shared Bruno CharlieriD· 1 shared Carmen FestaiD· 1 shared Carmen Massa· 1 shared Cristina Di GiorgioiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Angela ZampellaORCID

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2 papers

Recent·Most cited

BioinformaticsACS OmegaPeer-reviewedAug 13, 2026

From Structure to Dynamics: Activation Mechanism of the G Protein-Coupled Bile Acid Receptor 1-Gs Complex

Bianca Fiorillo, Federica Moraca, Francesco Saverio Di Leva…·Bruno Catalanotti

This study investigates how lithocholic acid modulates GPBAR1 activation and G protein engagement through molecular dynamics simulations and structural analysis.

DOI 10.1021/acsomega.6c02725

protein structuremixed model

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ImmunologyBiomedicine & PharmacotherapyPeer-reviewedDec 1, 2024

A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease

Michele Biagioli, Cristina Di Giorgio, Carmen Massa…·Stefano Fiorucci

This study identifies 3-oxo-DCA as a microbial bile acid that acts as a GPBAR1 agonist and RORγt inverse agonist, reversing inflammation in IBD.

54 citationstop 1%

mousemetabolomics

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