Zuriñe Antón

Kinase-gated coincidence detection controls kinesin-driven lysosome transport

The paper identifies a phosphorylation-dependent gate on kinesin-1 activity mediated by KLC2 CTD, revealing a kinase-kinase code that regulates lysosome transport through adaptor binding and membrane cues.

Variability in mitochondrial import, mitochondrial health and mtDNA copy number using Type II and Type V CRISPR effectors

This study evaluates the effectiveness of different CRISPR effectors for targeting mitochondria, finding that LbCas12a shows better targeting and tolerance than Cas9 variants.