Author

Laura O’Regan

University of BristolORCID 0000-0002-6101-6300Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

Derek N. WoolfsoniD· 2 shared Jessica A. CrossiD· 2 shared Mark P. DoddingiD· 2 shared Andrew M. FryiD· 1 shared Anna BodzętaiD· 1 shared Axel KnebeliD· 1 shared Christiane SchaffitzeliD· 1 shared Douglas J. LamontiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Derek N. WoolfsonORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Kinase-gated coincidence detection controls kinesin-driven lysosome transport

Laura O’Regan, Sarah Bristow, Zuriñe Antón, Anna Bodzęta, Jessica A. Cross, Derek N. Woolfson, Mark P. Dodding

The paper identifies a phosphorylation-dependent gate on kinesin-1 activity mediated by KLC2 CTD, revealing a kinase-kinase code that regulates lysosome transport through adaptor binding and membrane cues.

bioRxiv · Mar 28, 2026 · PreprintCell Biology

NEK7 phosphorylation of cortactin modulates the migratory capacity of cells expressing EML4-ALK V3

Emily L. Richardson, Axel Knebel, Kees R. Straatman, Robert Gourlay, Douglas J. Lamont, Tara Hardy, Robert E. Turnbull, Susan W. Robinson, Laura O’Regan, Richard W. Bayliss, Andrew M. Fry

This study identifies NEK7-mediated phosphorylation of cortactin as a mechanism by which EML4-ALK V3 enhances cell migration through actin cytoskeleton remodeling.

Scientific Reports · Jan 27, 2026Peer-reviewedCell Biology

Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch

Shivam Shukla, Jessica A. Cross, Monika Kish, Sathish K.N. Yadav, Johannes F. Weijman, Laura O’Regan, Judith Mantell, Ufuk Borucu, Xiyue Leng, Christiane Schaffitzel, Jonathan J. Phillips, Derek N. Woolfson, Mark P. Dodding

This study shows that cargo-sensitive TPR switch in kinesin-1 controls its conformational dynamics by dislocating the TPR shoulder, promoting motor domain activation and microtubule binding.

bioRxiv · Apr 8, 2025Biochemistry