Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1.
Yosuke Ochiai, Hiroki Kobayashi, Masaki Sunagawa, Taisuke Baba, Ermanno Malagola, Feijing Wu, Takayuki Tanaka, Masahiro Hata, Junya Arai, Zhengyu Jiang, Ruth Aroon White, Xiaofei Zhi, Jin Qian, Quin T. Waterbury, Ru‐Hong Tu, , Timothy Cragin Wang
This study identifies NTN1/NEO1 as a key driver of pancreatic tumorigenesis and metastasis by promoting cancer stemness, EMT, and nerve innervation.
bioRxiv · Jul 22, 2025 · PreprintCancer Biology