Jin Qian

A microbiota-driven neuroepithelial feed-forward circuit drives gastroesophageal junction tumorigenesis

This paper identifies a microbiota-driven neuroepithelial circuit that promotes GEJ tumorigenesis through bile acid remodeling and bacterial metabolites.

Endocrine Neural Interactions Regulate Antral CCK2R+ Stem Cells in Gastric Inflammation and Preneoplasia

The paper shows that gastrin loss activates a vagal reflex that promotes CCK2R+ stem cell expansion and preneoplasia in gastric inflammation.

Sensory neurons encode long-term inflammatory memory that promotes gastric regeneration and tumorigenesis

This paper shows that sensory neurons form long-term inflammatory memory, enhancing gastric regeneration and tumor susceptibility after injury.

Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury

This study identifies Tff2+ progenitors in the gastric corpus as the primary source of SPEM and gastric cancer following injury, showing they can bypass metaplasia and progress directly to dysplasia.

Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1.

This study identifies NTN1/NEO1 as a key driver of pancreatic tumorigenesis and metastasis by promoting cancer stemness, EMT, and nerve innervation.

Macrophage ferroptosis inhibits Aspergillus conidial killing in lung transplantation

This study shows that macrophage ferroptosis impairs Aspergillus killing in lung transplant recipients, increasing fungal infection risk.

DNA Methylation-Based Cell Type Deconvolution Reveals the Distinct Cell Composition in Brain Tumor Microenvironment

This paper introduces MDBrainT, a DNA methylation-based deconvolution method to predict cell composition in brain tumor microenvironments, revealing distinct patterns across tumor types and molecular subtypes that correlate with patient outcomes.

A CXCR4 partial agonist improves immunotherapy by targeting polymorphonuclear myeloid-derived suppressor cells and cancer-driven granulopoiesis

This paper shows that a CXCR4 partial agonist enhances immunotherapy in gastric cancer by targeting PMN-MDSCs and granulopoiesis.