Author

Constanza García‐Keller

Medical College of WisconsinORCID 0000-0002-3141-9571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexander C.W. SmithiD· 2 shared Juan Pablo Taborda-BejaranoiD· 2 shared Michael E. Meyerink· 2 shared Adam R. DentoniD· 1 shared Annaka M. Westphal· 1 shared Arthur C. RiegeliD· 1 shared Ashley G. Brock· 1 shared Aubin MoutaliD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Alexander C.W. SmithORCID

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4 papers

Recent·Most cited

CSF1R-Mediated Microglial Engagement Is Required for Stress-Induced MMP-2/9 Activity

Juan Pablo Taborda-Bejarano, Juliana Patricia Tovar, Malika Allen, Jayashree Natarajan, Michael E. Meyerink, Constanza García‐Keller

This study shows that microglial CSF1R signaling is required for stress-induced MMP-2/9 activity in the nucleus accumbens core.

bioRxiv · Jun 11, 2026 · PreprintNeuroscience

DUSP5 Downregulation in Nucleus Accumbens Core Correlates with Synaptic Plasticity and Cue-Induced Cocaine Reinstatement

Juan Pablo Taborda-Bejarano, Michael E. Meyerink, Debbie C. Crans, Ramani Ramchandran, Constanza García‐Keller

This study investigates the role of DUSP5 in cocaine-induced synaptic plasticity and cue-induced cocaine reinstatement using a rat model and single-cell RNA sequencing data.

bioRxiv · Sep 19, 2025 · PreprintNeuroscience

Accumbens Nitrergic Interneurons Drive the Cell Type-Specific Synaptic Plasticity Required for Cue-Induced Cocaine Seeking

Adam R. Denton, Rachel E. Clarke, Lisa M. Green, Jayda Carroll-Deaton, Annaka M. Westphal, Benjamin M. Siemsen, Ashley G. Brock, Elizabeth A. Hochberg, Jacob Lavine, Makoto Taniguchi, Jacqueline F. McGinty, Alexander C.W. Smith, Constanza García‐Keller, James M. Otis, Michael D. Scofield

This paper identifies nitrergic interneurons as key mediators of cue-induced synaptic plasticity in D1 MSNs required for cocaine seeking, showing that targeting nNOS or mGluR5 blocks relapse.

bioRxiv · Apr 5, 2024 · PreprintNeuroscience

Dynamic CRMP2 regulation of CaV2.2 in the prefrontal cortex contributes to the reinstatementof cocaine seeking

William C. Buchta, Aubin Moutal, Bethany Hines, Constanza García‐Keller, Alexander C.W. Smith, Peter W. Kalivas, Rajesh Khanna, Arthur C. Riegel

This study investigates how CRMP2 and CaV2.2 interactions in the prefrontal cortex influence cocaine-seeking behavior and relapse.

Molecular Neurobiology · Jul 29, 2019Peer-reviewedNeuroscience