Junyoung O. Park

Deformability screening identifies NUDT5 as a mediator of cellular mechanobiology

The paper screens compounds to identify mechanical mediators by measuring cell deformability, finding NUDT5 as a key mediator in ovarian cancer.

High energy charge, antioxidant capacity, and amino acid contents are conserved features of T cell metabolism

The paper quantifies T cell metabolomes across subtypes and individuals, revealing conserved features that support immune response readiness.

Robustness of mitochondrial biogenesis and respiration explain aerobic glycolysis

The paper explains aerobic glycolysis as a result of mitochondrial respiration saturation and decoupling of mitochondrial biogenesis from other cellular processes.

Accurate and rapid determination of metabolic flux by deep learning of isotope patterns

This paper introduces ML-Flux, a deep learning framework for accurately and rapidly determining metabolic flux from isotope patterns, outperforming existing methods in speed and accuracy.

Extracellular Domains of CAR Reprogram T-Cell Metabolism Without Antigen Stimulation

This study shows that CAR extracellular domains reprogram T-cell metabolism independently of antigen stimulation, with distinct metabolic effects observed between different CARs.

A parallel glycolysis supports rapid adaptation in dynamic environments

The paper identifies that the Entner-Doudoroff pathway provides a metabolic advantage in dynamic nutrient environments by enabling faster response times during nutrient upshifts.

A two-enzyme adaptive unit in bacterial folate metabolism

The paper investigates adaptive dependencies between enzymes in bacterial folate metabolism, showing that DHFR and TYMS form a modular unit that can adapt independently from the rest of the genome.