Author

Ali Sinan Saglam

University of PittsburghORCID 0000-0002-6513-8401Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:software / tool· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:simulation· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

James R. FaederiD· 3 shared Aarthi NarayananiD· 1 shared Adrianne L. JenneriD· 1 shared Amber M. SmithiD· 1 shared Andrew BeckeriD· 1 shared Ashlee N. Ford VersyptiD· 1 shared Bing LiuiD· 1 shared Caroline I. LarkiniD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

James R. FaederORCID

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3 papers

Recent·Most cited

WEBNG: A templating tool for weighted ensemble sampling of rule-based models

Ali Sinan Saglam, James R. Faeder

WEBNG simplifies rare event sampling in rule-based models by integrating BioNetGen and WESTPA, enabling efficient simulation with default parameters.

bioRxiv · Oct 28, 2022 · PreprintSystems Biology

Combination Treatment Optimization Using aPan-Cancer Pathway Model

Robin Schmucker, Gabriele Farina, James R. Faeder, Fabian Fröhlich, Ali Sinan Saglam, Tüomas Sandholm

This paper uses a pan-cancer pathway model to identify novel combination therapies and optimize treatment sequences for cancer cell lines.

PLoS Computational Biology · Dec 28, 2021Peer-reviewedSystems Biology

Iterative community-driven development of a SARS-CoV-2 tissue simulator

Michael Getz, Yafei Wang, Gary C. An, Maansi Asthana, Andrew Becker, Chase Cockrell, Nicholson T. Collier, Morgan Craig, Courtney L. Davis, James R. Faeder, Ashlee N. Ford Versypt, Tarunendu Mapder, Juliano F. Gianlupi, James A. Glazier, Sara Hamis, , Paul Macklin

Open-source agent-based PhysiCell model of SARS-CoV-2 infection in lung epithelium; version 5 clears virus in about 6 days in simulation, and delayed T cell arrival increases epithelial loss.

bioRxiv · Apr 2, 2020 · PreprintSystems Biology✦ In-depth digest