Niamh C. Nowlan

This study shows maternal exercise rescues skeletal defects in fetal akinesia by directly stimulating fetal joint and bone development through mechanical forces.

This study examines postnatal bone development in goats, showing rapid cortical bone densification and unique postnatal synostosis in metacarpal epiphyses.

The paper shows mechanical loading is critical for collagen network formation during prenatal skeletal development in mice.

This study identifies cyclical compression loading as critical for normal joint morphogenesis in zebrafish, showing that dynamic mechanical stimuli, not static compression, regulate joint shape and growth.

This study investigates the role of TRPV4 in mechanically regulated prenatal skeletal development, showing its importance in joint cartilage growth and shape through mechanotransduction.

This study shows YAP and TAZ regulate osteoblast precursor mobilization and angiogenesis during bone development, linking mechanical cues to vascular and bone formation.

This study examines how the absence of skeletal muscle affects prenatal skeletal development in mice, finding that most effects diminish over time, except for joint cavitation.

This study uses computational modeling to show that growth orientation, not growth rate, primarily drives jaw joint morphogenesis in larval zebrafish.

This study quantifies how reduced or absent muscle affects joint shape in mouse embryos, finding that reduced muscle has more pronounced effects than absent muscle, particularly on the elbow joint.