Cancer BiologybioRxivPreprint
B12 promotes gut dysbiosis and an inflammatory microenvironment that potentiates Tet2-deficient hematopoiesis.
Peter D. Lyon, Tiffany E. Leesang, John P Brabson…·Luisa Cimmino
This study shows that B12 supplementation promotes gut dysbiosis and inflammation, which enhances myelopoiesis in Tet2-deficient mice, suggesting a microbiome-mediated mechanism for clonal hematopoiesis.
1 citation