B12 promotes gut dysbiosis and an inflammatory microenvironment that potentiates Tet2-deficient hematopoiesis.
Peter D. Lyon, Tiffany E. Leesang, John P Brabson, KTT Do, Molly Dalzell, Luis Alberto Nivelo, Minh Quang Lam, Ana Peci, Byron Fang, Victoria Strippoli, AA Armand, Praveen Kumar Singh, Sabita Roy, Felipe Beckedorff, Alejandro V. Villarino, Luisa Cimmino
This study shows that B12 supplementation promotes gut dysbiosis and inflammation, which enhances myelopoiesis in Tet2-deficient mice, suggesting a microbiome-mediated mechanism for clonal hematopoiesis.
bioRxiv · Aug 22, 2025 · PreprintCancer Biology