Author

Srikanth Sadhu

Translational Health Science and Technology InstituteORCID 0000-0002-0236-265XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Amit AwasthiiD· 2 shared Sweety SamaliD· 2 shared Abhay Deep PandeyiD· 1 shared Abhigya ChhetriiD· 1 shared Arup Kumar BanerjeeiD· 1 shared Dipanjali Sinha· 1 shared Divya GuptaiD· 1 shared Gazala SiddquiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Amit AwasthiORCID

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2 papers

Recent·Most cited

Dengue Virus Serotype 2 Infection Transcriptionally Reprograms Host Neutrophils to Establish an Immunosuppressive Microenvironment in Mice

Surender Rawat, Abhigya Chhetri, Sakshi Nimesh, Abhay Deep Pandey, Srikanth Sadhu, Gazala Siddqui, Sweety Samal, Amit Awasthi, Arup Kumar Banerjee

This study shows that Dengue virus serotype 2 reprograms neutrophils in mice to create an immunosuppressive environment, with FGL2-expressing neutrophils playing a key role.

bioRxiv · Oct 30, 2026 · PreprintImmunology

Anti-COVID-19 Activity of FDA Approved Drugs through RNA G-quadruplex Binding

Shuvra Shekhar Roy, Shalu Sharma, Zaigham Abbas Rizvi, Dipanjali Sinha, Divya Gupta, Mercy Rophina, Paras Sehgal, Srikanth Sadhu, Manas Ranjan Tripathy, Sweety Samal, Souvik Maiti, Vinod Scaria, Sridhar Sivasubbu, Amit Awasthi, Krishnan Harinivas Harshan, , Shantanu Chowdhury

This study identifies FDA-approved drugs that bind G-quadruplexes in SARS-CoV-2 genomes, showing significant inhibition of viral replication in hamsters and cell cultures comparable to Remdesivir.

bioRxiv · May 31, 2022 · PreprintMolecular Biology