Souvik Maiti

This paper presents a scalable workflow for producing high-purity circular single-stranded DNA using an M13 phagemid system, achieving yields of 120-195 µg from 300 mL culture.

This paper introduces a dual-affinity PNA (daPNA) platform that targets miR-21 precursor, inhibits Dicer activity, and rescues PTEN expression by blocking miR-21 maturation.

CriSNPr provides a webserver for designing and querying gRNAs for CRISPR-based diagnostics using multiple Cas systems and includes a curated database of gRNAs for human and SARS-CoV-2 variants.

This study identifies TOBF1 as a regulator of alternative splicing in mouse embryonic stem cells, showing its role in maintaining stem cell identity through co-transcriptional mechanisms.

This study identifies FDA-approved drugs that bind G-quadruplexes in SARS-CoV-2 genomes, showing significant inhibition of viral replication in hamsters and cell cultures comparable to Remdesivir.

FELUDA uses FnCas9 for rapid, accurate nucleobase detection and is implemented in a point-of-care diagnostic tool for SARS-CoV-2.

This study identifies DNA sequences that dIno80 binds with high specificity and shows this interaction positively regulates transcription.

This paper demonstrates that Francisella novicida Cas9 (FnCas9) has high specificity and low off-target editing, enabling precise genome editing in mammalian cells.

The paper identifies novel circadian transcripts in the zebrafish retina and distinguishes between light-entrained and free-running oscillations.

This study shows aminoglycoside antibiotics like streptomycin modulate miRNA levels, leading to ototoxicity by perturbing the miR-96 cluster in zebrafish neuromasts.