This study evaluates a full-length 16S rRNA sequencing framework for species-resolved human gut microbiome profiling, showing improved taxonomic resolution compared to short-read methods.

bioRxiv · Jun 23, 2026 · PreprintGenomics

SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function

Gyan Ranjan, Paras Sehgal, Vinod Scaria, Sridhar Sivasubbu

This paper identifies and functionally validates the scar-6 lncRNA locus, showing it regulates prozb expression and modulates coagulation and vascular function in zebrafish through epigenetic mechanisms.

EMBO Reports · Oct 2, 2024Peer-reviewedGenetics

Anti-COVID-19 Activity of FDA Approved Drugs through RNA G-quadruplex Binding

Shuvra Shekhar Roy, Shalu Sharma, Zaigham Abbas Rizvi, Dipanjali Sinha, Divya Gupta, Mercy Rophina, Paras Sehgal, Srikanth Sadhu, Manas Ranjan Tripathy, Sweety Samal, Souvik Maiti, Vinod Scaria, Sridhar Sivasubbu, Amit Awasthi, Krishnan Harinivas Harshan, , Shantanu Chowdhury

This study identifies FDA-approved drugs that bind G-quadruplexes in SARS-CoV-2 genomes, showing significant inhibition of viral replication in hamsters and cell cultures comparable to Remdesivir.

bioRxiv · May 31, 2022 · PreprintMolecular Biology

Rapid, accurate, nucleobase detection using FnCas9

Mohd. Azhar, Rhythm Phutela, Manoj Kumar, Asgar Hussain Ansari, Riya Rauthan, Sneha Gulati, Namrata Sharma, Dipanjali Sinha, Saumya Sharma, Sunaina Singh, Sundaram Acharya, Sajal Sarkar, Deepanjan Paul, Poorti Kathpalia, Meghali Aich, , Souvik Maiti

FELUDA uses FnCas9 for rapid, accurate nucleobase detection and is implemented in a point-of-care diagnostic tool for SARS-CoV-2.

Biosensors and Bioelectronics · Apr 5, 2021Peer-reviewedGenetic & Genomic Medicine

Initial insights into the genetic epidemiology of SARS-CoV-2 isolates from Kerala suggest local spread from limited introductions

Chandni Radhakrishnan, Mohit Kumar Divakar, Abhinav K. Jain, Prasanth Viswanathan, Rahul C. Bhoyar, Bani Jolly, Mohamed Imran, Disha Sharma, Mercy Rophina, Gyan Ranjan, Paras Sehgal, Beena Philomina Jose, Rajendran V Raman, Nallaveettil Kesavan Thulaseedharan, Kalpana George, , Vinod Scaria

The paper analyzes SARS-CoV-2 isolates from Kerala, India, identifying 166 unique variants, including 4 novel ones, and reports on their genetic epidemiology and potential impact on diagnostics.

Frontiers in Genetics · Mar 17, 2021Peer-reviewedGenomics

High throughput detection and genetic epidemiology of SARS-CoV-2 using COVIDSeq next generation sequencing

Rahul C. Bhoyar, Abhinav K. Jain, Paras Sehgal, Mohit Kumar Divakar, Disha Sharma, Mohamed Imran, Bani Jolly, Gyan Ranjan, Mercy Rophina, Sumit Sharma, Sanjay Siwach, Kavita Pandhare, Swayamprabha Sahoo, Maheswata Sahoo, Ananya Nayak, , Sridhar Sivasubbu

This study evaluates the COVIDSeq protocol for SARS-CoV-2 detection and genetic epidemiology, showing high concordance with RT-PCR and identifying novel variants and lineages.

PLoS ONE · Feb 17, 2021Peer-reviewedGenomics

Insights from Genomes and Genetic Epidemiology of SARS-CoV-2 isolates from the state of Andhra Pradesh

Pallavali Roja Rani, Mohamed Imran, Juturu Vijaya Lakshmi, Bani Jolly, S. Afsar, Abhinav K. Jain, Mohit Kumar Divakar, Panyam Suresh, Disha Sharma, Nambi Rajesh, Rahul C. Bhoyar, Dasari Ankaiah, Sanaga Shanthi Kumari, Gyan Ranjan, Valluri Anitha Lavanya, , Sridhar Sivasubbu

This study sequenced SARS-CoV-2 genomes from Andhra Pradesh, identifying 564 variants including 15 novel ones and 4 associated with increased infectivity.

Epidemiology and Infection · Jan 1, 2021Peer-reviewedGenomics

A genome-wide circular RNA transcriptome in Rat

Disha Sharma, Paras Sehgal, Sridhar Sivasubbu, Vinod Scaria

The paper identifies and characterizes circular RNAs in rat using multiple computational pipelines and validates some candidates through experimental methods.

Biology Methods and Protocols · Jan 1, 2021Peer-reviewedMolecular Biology

Genetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomes

Bani Jolly, Mercy Rophina, Afra Shamnath, Mohamed Imran, Rahul C. Bhoyar, Mohit Kumar Divakar, Pallavali Roja Rani, Gyan Ranjan, Paras Sehgal, Pulala Chandrasekhar, S. Afsar, Juturu Vijaya Lakshmi, Avileli Surekha, Sridhar Sivasubbu, Vinod Scaria

The paper investigates the genetic epidemiology of immune escape variants in SARS-CoV-2 genomes globally.

bioRxiv · Dec 24, 2020 · PreprintBioinformatics