Author

C. William Shuttleworth

University of New MexicoORCID 0000-0002-0237-4888Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew Phillip CarlsoniD· 3 shared Russell A. MortoniD· 3 shared Jordan E. WeisendiD· 2 shared Katelyn M. Reinhart· 2 shared M. Catherine BennettiD· 2 shared Ala SomarowthuiD· 1 shared Antoneta KarajiD· 1 shared Arianna PuglieseiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersNeuroscience

Andrew Phillip CarlsonORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Initiation site of experimentally-evoked spreading depolarizations influence tissue outcomes in a murine stroke model

M. Catherine Bennett, Russell A. Morton, Andrew Phillip Carlson, C. William Shuttleworth

This study shows that the location of experimentally-induced spreading depolarizations (SDs) in a mouse stroke model affects infarct size, with SDs near the infarct core increasing damage and those in remote areas reducing it.

Experimental Neurology · Jan 28, 2026Peer-reviewedNeuroscience

Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans

Zachary P. Rosenthal, Joseph B. Majeski, Ala Somarowthu, Davin K. Quinn, Britta E. Lindquist, Mary E. Putt, Antoneta Karaj, Christopher G. Favilla, Wesley B. Baker, Golkoo Hosseini, Jenny P. Rodriguez, Mario A. Cristancho, Yvette I. Sheline, C. William Shuttleworth, Chris Abbott, , Ethan M. Goldberg

This study shows that electroconvulsive therapy (ECT) induces a postictal wave of spreading depolarization in both mice and humans, suggesting a new mechanism for its therapeutic effects.

Nature Communications · May 18, 2025Peer-reviewedNeuroscience

Synaptic Zn2+ contributes to deleterious consequences of spreading depolarizations

M. Catherine Bennett, Katelyn M. Reinhart, Jordan E. Weisend, Russell A. Morton, Andrew Phillip Carlson, C. William Shuttleworth

This study investigates the role of synaptic Zn2+ release in spreading depolarizations and shows that pharmacological chelation can improve recovery in vulnerable conditions.

Neurobiology of Disease · Jan 8, 2024Peer-reviewedNeuroscience

Repetitive Spreading Depolarization induces the activation of cell differentiation, synaptic plasticity and neuroprotective pathways.

Michela Dell’Orco, Jordan E. Weisend, Nora I. Perrone‐Bizzozero, Andrew Phillip Carlson, Russell A. Morton, David N. Linsenbardt, C. William Shuttleworth

This study identifies gene expression changes in brain tissue following spreading depolarization, showing activation of pathways related to cell differentiation, synaptic plasticity, and neuroprotection.

Frontiers in Cellular Neuroscience · Dec 14, 2023Peer-reviewedNeuroscience

Non-canonical glutamate signaling in a genetic model of migraine with aura

Patrick D. Parker, Pratyush S. Suryavanshi, Marcello Melone, Punam Sawant-Pokam, Katelyn M. Reinhart, Dan Kaufmann, Jeremy J. Theriot, Arianna Pugliese, Fiorenzo Conti, C. William Shuttleworth, Daniela Pietrobon, K. C. Brennan

The paper identifies non-canonical glutamate signaling in a migraine model, linking it to spreading depolarizations and potential therapeutic targets.

Neuron · Dec 15, 2020Peer-reviewedNeuroscience