Mel Β. Feany

The paper fine-maps PD GWAS signals across cell types, revealing convergent glial-neuronal risk genes and a shared vesiculopathy network.

This study integrates multi-omics data from Drosophila and human Alzheimer's disease models to identify pathways involved in neurodegeneration.

This study creates a Drosophila tauopathy model with the P251L mutation and uses single-cell RNA sequencing to identify molecular changes in neuronal and glial cells.

The paper identifies a shared genetic risk module involving PSEN2 and actin regulation across alpha-synucleinopathies, linking them to Alzheimer's disease mechanisms.

The paper identifies pathways controlling neurodegeneration and proteostasis in mitochondrial complex I deficiency using a Drosophila model and genetic screens.

The paper identifies a conserved role for APP in proteostasis during aging through genetic and multi-omics analyses in Drosophila and human models.

This study identifies circRNAs specific to dopamine and pyramidal neurons and links them to neuropsychiatric diseases.

This study identifies β-spectrin as a key binding partner of α-synuclein, showing that their interaction disrupts the spectrin-ankyrin complex, leading to neuronal dysfunction and death in Parkinson's disease and related disorders.

The paper investigates how nicotine interacts with the SV2 gene to mitigate α-synuclein toxicity in a Drosophila model of Parkinson's disease, showing that SV2 is necessary for nicotine's protective effect.

This paper introduces a new rat model of Alexander disease that exhibits key pathological features and motor impairment, demonstrating that antisense oligonucleotide therapy can reverse GFAP pathology and white matter deficits.