Jenny Jie Yang

Unmasking Early Hepatorenal Fibrosis in Polycystic Kidney Disease Using Noninvasive Precision Molecular MRI of Collagen

This paper develops a collagen-targeting MRI contrast agent to noninvasively detect early fibrosis in ADPKD, showing improved detection compared to standard agents.

mRNA-LNP therapy restores systemic nucleoside imbalance in a mitochon-drial DNA depletion syndrome

This study develops mRNA-LNP therapy for MNGIE, restoring nucleoside balance and TP expression in mice through subcutaneous delivery.

Organellular imaging in vivo reveals a depletion of endoplasmic reticular calcium during post-ictal cortical spreading depolarization

The paper uses in vivo imaging to show that cortical spreading depolarization depletes endoplasmic reticulum calcium, linking ER dynamics to seizure suppression.

Mannose is crucial for mesoderm specification and symmetry breaking in gastruloids

This study shows that mannose is essential for mesoderm specification in gastruloids, while the glycolytic pathway is not required for early T/Bra expression.

Arc ubiquitination regulates endoplasmic reticulum-mediated Ca2+ release and CaMKII signaling

This study shows that Arc ubiquitination regulates ER-mediated Ca2+ release and CaMKII signaling during mGluR-LTD.